Hiroshima University, Public Relations Group
E-mail: koho[at]office.hiroshima-u.ac.jp (Change [at] into @)
1-3-2 Kagamiyama, Higashi-Hiroshima City, Hiroshima, Japan 739-8511
Faculty Information Details
All data is as of April 28, 2025.
- HASHIMOTO YOSUKE
| Affiliation | |
|---|---|
| Discipline | Medical Life Science |
| Academic Degrees |
The University of Tokushima Osaka University |
| Research Fields | |
| Research Keywords | Blood-brain barrier / Tight junction / Claudin-5 / Monoclonal antibody |
| Comments |
I am an assistant professor in Prof. Yasuo Uchida lab in Hiroshima University. I received my Ph.D (pharmacology) in Osaka University in Japan and I have completed postdoctoral training in Prof. Matthew Campbell lab in Trinity College Dublin. My research interests are <i>CLDN5</i> gene and claudin-5 protein in the blood-brain barrier. The function and expression level of claudin-5 are critical in determining the onset/frequency/severeness of a range of neurological diseases, especially epilepsy, psychiatric disorders and cognitive decline. I have developed anti-claudin-5 monoclonal antibodies that can disturb the junctional localization of claudin-5 by steric inhibition. Added to this, I have discovered a novel pathogenic <i>CLDN5</i> missense mutation that causes alternating hemiplegia of childhood with epilepsy and brain stem calcification. We discovered this mutant creates anion-permeable tight junctions by converting the barrier forming function of claudin-5. I'd like to develop drugs that can control claudin-5 expression/function to treat abnormal claudin-5 related neurological diseases. |
| Profiles of Faculty and Research Scholars |
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| Past media appearances | |
| Topic | |
| SDGs | |
| Educational Programs |
[Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences |
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